what are the side effects of cerenia for dogs what are the side effects of cerenia for dogs

Interpretation of these study results is complicated by the health status of study animals. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Wash hands with soap and water after administering drug. Your veterinarian may recommend other antiemetic medications or dietary changes to alleviate your dogs symptoms. How long does it take for Cerenia to work? The empirical formula is C32H40N2O C6H8O7 H2O and the molecular weight 678.81. Where the dogs treated ethically? However, its essential to give the medication time to work, and your dog may need to take Cerenia for several days to see the full benefits. In the first phase the dogs were administered 0, 20 or 30 mg/kg orally once daily for 7 days and in the second phase 0, 40, or 50 mg/kg once daily for 7 days. Keep in mind, most dogs take Cerenia with no adverse reactions, but the most common reported side effects are as follows: Lethargy Drowsiness Excessive drooling Lack of appetite Diarrhea Is there an alternative I can turn to? Cerenia Tablets administered at 40 mg/kg and 50 mg/kg caused clinically relevant signs of weight loss, vomiting, soft stools, weakness, lethargy, salivation and hypokalemia. Soon, the toxin will be absorbed by the body which may lead to important complications and even death. If youre introducing your pet to the medication for the first time, its wise to set out on a test drive before hitting the road for the real trip. Cerenia will take effect quickly, and improvement signs in your dog . Following is some information about Cerenia and the several side effects of Cerenia in dogs. Masking the symptoms leads to delayed diagnosis and treatment. DeckersN, RuigrokCA, VerhoeveHP, etal. The concomitant use of Cerenia with other protein bound drugs has not been studied in dogs. If you have concerns due to a longer, upcoming trip, ask your veterinarian what options you have to prevent motion sickness vomiting. Cerenia is a medication that is FDA-approved to treat vomiting in dogs and cats and help prevent motion sickness in dogs. Acute vomiting symptoms include continuous vomiting. Cerenia is prescription only. Speak with your veterinarian about what to do if you forget to give a dose of Cerenia (maropitant citrate). These work hand-in-hand with other treatment options to help you pet be pain-free and happy. Loss or lack of appetite. Get practical pet health tips, articles, and insights from our veterinary community delivered weekly to your inbox. All in all, Cerenia does have a range of side effects. If your dog shows any of these symptoms after taking Cerenia, contact your vet immediately. In Veterinary Anaesthesia (Eleventh Edition), 2014. Other Cerenia side effects in dogs include inflammation of the ear (3 dogs out of 206, 1.5 percent), endotoxic shock (2 dogs out of 206, 1 percent), blood in urine (2 dogs out of 206, 1 percent) excoriation, presence of erosion or ulceration caused by scratching, biting or rubbing (2 dogs out of 206, 1 percent). Receive 25% off your next order when you share your testimonial with us! Track all medical history, medications, and dietary changes in your pet to find what works. Travel is no exception. One of the most common side effects of Cerenia is drowsiness or lethargy. The rare side effects of Cerenia can include: Diarrhea. Cerenia is given orally. The side effects of Cerenia for dogs is something for dog owners to watch for so to take prompt action should any arise. If you suspect an overdose, immediately seek emergency veterinary care, or contact an animal poison control center. Overeating plus continued movement can lead to an upset stomach for your dog. Forty Beagle dogs (20 males and 20 females) between 16 18 weeks of age were administered Cerenia Tablets orally once daily for 6 days at 0, 8 and 24 mg/kg. Cerenia side effects for dogs are usually temporary, mild and not serious. Your email address will not be published. The drug information leaflet though fails going into more specific details which may be insightful for concerned puppy and dog owners. Gabapentin (brand names: Neurontin, Aclonium, Equipax, Gantin, Gabarone, Gralise, Neurostil, Progresse) is an anti-seizure and pain medication that is used with other medications to treat seizures and is also used to treat chronic pain, primarily nerve pain. Cerenia can also be used to stop vomiting through drug overdose, gastrointestinal obstruction, central nervous system disease, hypercalcemia and uremia. Keep the tablets in the supplied blister packs until use to protect from moisture and light. Interpretation of these study results is complicated by the health status of study animals. In puppies 16 weeks and older, bone marrow hypoplasia was not seen (See Animal Safety Section). Topical exposure to Cerenia (maropitant citrate) may elicit localized skin reactions in some individuals. Watch for other signs of illness in your pet and changes in appearance or behavior. According to the drug informational leaflet, when Cerenia was given once at a minimum dose of 8mg/kg to dogs prone to motion sickness, 26 dogs out of 208 (that's 12.5 percent) developed hypersalivation. However, if it is almost time for your next dose, your veterinarian may instruct you to skip the missed dose and resume your normal dosing schedule. If your dog appears to have developed decreased activity levels and tiredness ever since you have been giving him his Cerenia pills, you are not imagining things. Commonly used protein bound drugs include NSAIDs, cardiac, anticonvulsant and behavioral medications. The most common side effects of Cerenia include drowsiness, lethargy, and diarrhea. But your veterinarian will determine if it continues to be the best route of care for your pet. However, this can be cured, though by getting the dog lots and lots water. Where any steps take to reduce stress in dogs if housed in a laboratory? This could be due to a temporary illness, separation anxiety, or simply because he ate something he shouldnt have. In people, topical exposure may elicit localized allergic skin reactions, and repeated or prolonged exposure may lead to skin sensitization. Comparison of pain response after subcutaneous injection of two maropitant formulations to beagle dogs. The leaflet mentions 10 dogs dying out of 206 receiving Cerenia, which is 4.9 percent. Cerenia is designed to inhibit the processes in the brain that cause nausea and vomiting. We comply with the HONcode standard for trustworthy health information. Precautions and Side Effects; While generally safe and effective when prescribed by a veterinarian, maropitant citrate can cause side effects in some animals. Dogs given a placebo though apparently were not free from being affected. For other uses of this medication, please follow the directions on the drug label or as provided by your veterinarian. Maropitant is a neurokinin (NK1) receptor antagonist that blocks the pharmacological action of substance P in the central nervous system (CNS). Use with caution with other medications that are highly protein bound. The most common side effect of cerenia is diarrhea. In vivo model studies in dogs have shown that maropitant has antiemetic effectiveness against both central and peripheral emetogens including apomorphine, and syrup of ipecac. # dogs. The most common side effects are vomiting and hypersalivation at the higher doses required for motion sickness. There is limited information available on the use of Cerenia in pregnant or nursing dogs. These products are not intended to diagnose, treat, cure, or prevent any disease. Take your dog for a walk and let him get out his energy prior to traveling, especially if youre going to be on a long flight or on a tight schedule when driving. One must ask why is the dog vomiting in the first place? Cerenia (maropitant citrate) is not approved for use in humans. Side effects of Cerenia may include drowsiness, lethargy, lack of appetite, and diarrhea. The medication is prescribed for use only once per day, typically to be administered before the actual start of the trip. It could be symptomatic of a larger problem, which may create its own larger action plan of care. Not for use in humans. Talk with your pets doctor about any medications or nutritional supplements your pet is currently receiving. While Cerenia is often used to treat vomiting, it can sometimes cause diarrhea or vomiting as a side effect. Finally, take as many breaks as you can. If the vomiting continues, your veterinarian may recommend Cerenia to control it from occurring. However, recently, a formulation containing benzyl alcohol has been reported to reduce the pain. Fortunately, most vets are quite thorough in ruling out underlying causes of vomiting in dogs that need to be addressed before thinking of administering a powerful drug as Cerenia. Maropitant. or stool, pain, and weakness. In laboratory model studies, Cerenia Tablets dosed at a minimum of 2 mg/kg BW reduced the number of emetic events associated with established neural (central) and humoral (peripheral) stimuli. For a copy of the Material Safety Data Sheet (MSDS) or to report adverse reactions call Pfizer Animal Health at 1-800-366-5288. By blocking it, Cerenia helps prevent these symptoms from occurring. According to a published study, oral maropitant is commonly used off label in cats at the same dose (1 mg/kg q24h), which differs from the labeled dose for dogs (2 mg/kg), probably due to the difference in . Beagle dogs approximately 8 weeks of age were administered Cerenia Tablets orally once daily for 15 days at 0, 2, 6, and 10 mg/kg using a protocol similar to the previous study. Dogs used in the study were weaned early, minimally acclimated to the test facility, and many of the dogs in the study tested positive for coccidia. If it is the result of your dogs diet, discuss alternatives with your veterinarian to introduce or eliminate foods as needed. There were 16 dogs (8 males and 8 females) in the 0 and 24 mg/kg groups and 8 dogs (4 males and 4 females) in the 8 mg/kg group. While side effects are uncommon, Cerenia for dogs can potentially cause: Vomiting Lethargy Drowsiness Muscle tremors Anorexia Diarrhea Loss of appetite Drooling Pain and swelling (at the injection site if injectable Cerenia is given) Consult your veterinarian if you think your dog may be experiencing any side effects of Cerenia. When prescribed, your dogs doctor will review all the side effects and potential risks to look out for. Studies show that while most dogs react normally to the drug, the following side of effects of Cerenia has been reported over the years: Excessive drooling. We might not think of dogs getting woozy in the car but it is the case in many pets. Can Cerenia cause any long-term side effects in dogs? Cerenia is not recommended for use in dogs less than 16 weeks old. As discussed above, one may speculate that there may be chances that these dogs might have succumbed to disease processes already present and that failed to be addressed. This will help you determine if its an ongoing problem or a one-time event. Other Cerenia side effects in dogs include inflammation of the ear (3 dogs out of 206, 1.5 percent), endotoxic shock (2 dogs out of 206, 1 percent), blood in urine (2 dogs out of 206, 1 percent) excoriation, presence of erosion or ulceration caused by scratching, biting or rubbing ( 2 dogs out of 206, 1 percent). Motion sickness signs to watch for include: Whining Excessive lip licking Yawning Drooling Trembling/shaking Excessive panting Vomiting How Cerenia for Dogs Works Cerenia helps prevent and manage vomiting. Hemp nutrition is one alternative pet owners are turning to as part of implementing an all-natural diet. Side Effects and/or Signs of Overdose: Side effects are rare but include diarrhea and decreased appetite. There were 8 dogs (4 males and 4 females) in the 2 mg/kg group and 16 dogs (8 males and 8 females) in all other groups. Cerenia is available in different tablet sizes depending on the size of your dog and generally is prescribed with minimal risk. Can Cerenia be used with other medications? Whether your dog develops side effects from the Cerenia may vary based on several factors. What are the side effects of Cerenia in dogs? The most common side effects seen in dogs and cats administered CERENIA are pain/vocalization (injectable), depression/lethargy, anorexia, anaphylaxis, ataxia, convulsions, hypersalivation, and vomiting. The drug should be used with caution in dogs with impaired liver function. If your dog experiences vomiting or diarrhea while taking Cerenia, they may become dehydrated. A dose dependent increase in severity of bone marrow hypoplasia was observed histologically. If your pet has accidentally overdosed on Cerenia, side effects may be similar, including loss of appetite, bloody stool, and diarrhea. However, its essential to consult with your veterinarian before giving your dog any new medication or supplements. , or simply because he ate something he shouldnt have. This receptor plays a crucial role in triggering vomiting and nausea. It specifically targets the part of the brain that triggers vomiting (called the emetic center). This means that roughly 3.9 percent were affected by the runs. Over time, your dog may become used to traveling and not require Cerenia or there could be a change in other medications that would not make your dog a good candidate for it anymore. In case of accidental eye exposure, flush with water for 15 minutes and seek medical attention. Motion sickness, a bad diet, or illness can cause vomiting. Rather than leave your dog at home when you hit the road, Cerenia may be prescribed by your veterinarian to help avoid this problem. The injectable formulation is FDA approved for use in both dogs and cats, but the tablets are only approved by the FDA for use in dogs at this time. Side Effects of Cytopoint Injection for Dogs. It is a prescription drug, which means that it needs to be prescribed by a licensed veterinarian, so you'll hardly find it over the counter somewhere.. Cerenia works in a way that it blocks particular receptors that cause vomiting, thus effectively . Cerenia Tablets administered at 20 and 30 mg/kg caused occasional vomiting. Pain/vocalization upon injection is a common side effect. If you are already en route, call an emergency veterinary clinic nearby. Symptoms of an overdose of Cereniamay include weight loss, vomiting, soft stools, weakness, lethargy, excessive drooling, decreased heart rate, changes in electrolyte levels and changes in your pets white blood cell count or their bone marrow. When in the car, its most likely due to motion sickness. . Always confirm storage requirements by reviewing the label. For many, dogs are like another member of the family and rarely are left behind regardless of the destination. Off Label Use of Drugs in Veterinary Medicine, How to Treat Bilious Vomiting Syndrome in Cats, Decreased energy level (lethargy) or sedation, Your pets condition worsens or does not improve with treatment. Acute vomiting symptoms include continuous vomiting, blood in the vomit or stool, pain, and weakness. Laboratory and field studies have demonstrated that Cerenia Tablets are well tolerated in dogs after oral administration. Prevention of Vomiting Due to Motion Sickness (minimum of 8 mg/kg) Adverse Reaction. References Did you know? Also, keep well out of reach of children who may be curious about the treats youre giving to the dog. From his dog training facility to kennels to neighbors who look after your pet from time to time, give them the medical history they may need when caring for your pet. Besides, Cerenia can also cause the dog to experience severe drowsiness. Its not available for over-the-counter purchase. If he is 14lbs he could be dosed as high as 60mgs to help with motion sickness, although most veterinarians would probably start at 24mgs to see if that is effective. If this should occur, it will require emergency veterinary attention, which is an important to consider wherever you are traveling. Following administration of syrup of ipecac (peripheral emetic stimuli) vomiting was observed in 33% (4 of 12) of Beagle dogs treated with Cerenia Tablets and in 83% (10 of 12) of Beagle dogs treated with placebo tablets. In some cases, prolonged use of Cerenia may lead to digestive issues, such as diarrhea or loss of appetite. Some dog owners report that their dog's stools may turn a bit on the mushy side when they are given Cerenia. See also My Dog Ate a 300 mg Gabapentin? How long do the side effects of Cerenia last? . However, its important to administer Cerenia at least an hour before the motion sickness-inducing activity to ensure its effectiveness. Disclaimer: These statements have not been evaluated by the U.S. Food and Drug Administration. Upon receiving your complaint, the drug company will have to submit a report of adverse drug experience to the FDA. In dogs 4 months and older, oral maropitant citrate should reach its maximum efficiency at about 2 hours after ingestion. Dogs may have experienced more than one of the observed adverse reactions. Cerenia is not recommended for use in dogs less than 16 weeks old. If your dog experiences these symptoms, its important to monitor them closely and contact your vet if they persist. Side effects and contraindications of Cerenia for dogs The adverse reactions that may occur associated with the administration of Cerenia in dogs include the following: Lethargy Vomiting (within two hours after administration of 8 mg/kg dose) Injection site pain when injected subcutaneously Vomiting is a complex process coordinated centrally by the emetic center which consists of several brainstem nuclei (area postrema, nucleus tractus solitarius, dorsal motor nucleus of the vagus) that receive and integrate sensory stimuli from central and peripheral sources and chemical stimuli from the circulation and the cerebro-spinal fluid. ASPCA Animal Poison Control (888) 426-4435. According to veterinarian Dr. Jennifer Coates, giving Cerenia on a schedule of five days ontwo days off, or every other day, helps prevents this side effect. If you're interested in the Havanese dog breed, then you'll need to learn more about this breed's coat. Anorexia, the medical term for a lack of appetite was observed in 3 out of 206 dogs studied. Even with doses exceeding the recommended dose, side effects are rare. This way you can monitor how well your dog is responding to the medication and if its a suitable option long-term. Cerenia is the first and only FDA-approved medication prescribed by veterinarians for dogs to help treat and help prevent vomiting caused by motion sickness. Most dogs will maintain a normal appetite while taking maropitant citrate, but a loss of appetite is a possible known side effect. Administer Cerenia Tablets 2 hours prior to travel. With a degree in Animal Behaviour and over a decade of practical animal husbandry experience, Hannah's articles cover everything from pet care to wildlife conservation. Cerenia (Maropitant Citrate) tablets are indicated for the prevention of acute vomiting and the prevention of vomiting due to motion sickness in dogs. Cerenia FDA Prescribing Information, Side Effects and Uses. Drugs.com, Accessed 17 Nov. 2017. In US field studies in veterinary patients, Cerenia Tablets and Injectable Solution were well tolerated in dogs presenting with various conditions including parvovirus, gastroenteritis, and renal disease. Cerenia is fairly new drug that may be given as an injection or given by mouth to dogs who are suffering from nausea and vomiting. This is about 8 percent of researched dogs. Uses of Maropitant Citrate (Cerenia) for Dogs and Cats; Maropitant citrate is used to treat vomiting and prevent vomiting associated with motion sickness in dogs. While it might be tempting to share your snacks when on the road, it might not be the healthiest for your pet, especially if his stomach is more sensitive when traveling. It's more likely the stress that's causing it - a normal reaction in dogs to any kind of stress. Yes, Cerenia is generally safe for dogs when used as directed by a veterinarian. If you notice any unusual behavior in your dog while theyre taking Cerenia, its important to let your vet know right away. www.cerenia.com/frequently-asked-questions.aspx. In a study of canine veterinary patients taken on a one-hour car journey and treated with either Cerenia Tablets at a minimum dose of 8 mg/kg BW or placebo tablets 2 hours prior to the journey, 67 of 122 (55%) of dogs vomited during the journey when treated with placebo while 8 of 122 (7%) vomited during the journey after treatment with Cerenia Tablets. Of course, not all dogs will develop this. Many veterinarians may use the tablets as a treatment for vomiting in an off-label manner, meaning in a way that has not been approved by the FDA. Cerenia peach-colored tablets are scored with a break line, and contain 16, 24, 60 or 160 mg of maropitant as maropitant citrate per tablet. Swelling or pain at the injection site has been seen with the administration of the injectable form. Vomiting and nausea are common side effects of Cerenia in dogs and cats. Aside from pain at the injection site, Cerenia can cause nausea, vomiting, and diarrhea. Dont let your pet travel on a full stomach or bladder. How can I tell if my dog is allergic to Cerenia? 2008;31(6):528-532. The leaflet also lists 2 dogs being euthanized during the study but there is no exact information as to why. Cerenia is generally safe for use in puppies over the age of eight weeks. Consult with your veterinarian or seek immediate veterinary medical attention if vomiting continues despite treatment with Cerenia. Although tempting, its not recommended to hide it in food like hot dogs or cheese because it may affect the absorption and effectiveness rate. These symptoms may include hives, swelling of the facial area, and/or difficulty breathing. This is called extra-label, or sometimes off-label use, because this use is not described on the drug label. Injectable maropitant is approved for the treatment of vomiting in cats, administered at a dose of 1 mg/kg IV or SC q24h for 5 days. Does cerenia make dogs lose their appetite? When dogs were given Cerenia at a minimum dose of8mg/kg to dogs prone to motion sickness for 2 days, 5 dogs out of 107 developed hypersalivation (almost 5 percent). Cerenia has not be evaluated whether it is safe to usein pregnant or nursing animals. How quickly does Cerenia work in dogs for prevention of vomiting due to motion sickness? There are other factors involved with prescription medication. Anxiety. Common Side Effects of Cerenia for Dogs Side effects of Cerenia may include drowsiness, lethargy, lack of appetite, and diarrhea. To make the trips enjoyable for all, find out what your dog needs to have a safe and comfortable ride. A study was conducted on the effectiveness of the version of the drug preserved withbenzyl alcohol and it was found to cause significantly less pain. In most cases, your veterinarian may instruct you to not give extra or double doses. CERENIA Tablets are recommended for dogs 8 weeks and older for prevention of acute vomiting and for dogs 16 weeks and older for prevention of vomiting due to motion sickness. No dogs were reported being euthanized though. Take into account what makes your dog comfortable at home and translate that as much as possible when on the road. Cerenia works on average within one hour of administration. Topical exposure may elicit localized allergic skin reactions in some individuals. J Vet Pharmacol Ther. To understand how it accomplishes this feat, you first need a crash course on the vomiting center of the brain. Does cerenia stimulate appetite? Can cerenia for dogs cause loss of appetite? And other side effects such as a watery movement. But when at home, it could be indicative of a variety of things. One dog in the 24 mg/kg/day group died of unknown causes on study day 2 and a dose dependent increase in occurrence and severity of bone marrow hypoplasia and lymphoid depletion was observed histologically. Cerenia is a medication thats commonly prescribed for dogs who suffer from motion sickness or vomiting. Excessive drooling, diarrhea, vomiting, loss of appetite, and mild pain (from injection) are a few common side effects of Cerenia for dogs It is never fun when your dog vomits! This prevents nausea and vomiting. The following adverse reactions were reported during a European field study for the prevention of vomiting due to motion sickness in dogs treated with Cerenia Tablets at a minimum of 8 mg/kg orally once daily for 2 consecutive days. Tags: cerenia for dogs, cerenia for dogs side effects, cerenia injection for dogs side effects. The most common ones are including nausea and lack of appetite. About 25% of all animals that receive the drug experience vomiting. This can include symptoms like swelling, hives, or difficulty breathing. So, what are the side effects of Cerenia for dogs? For example, allergies to the drug is always a possibility. How long does maropitant citrate last in cats? No specific monitoring is required for this medication, but your veterinarian may recommend routine testing depending on your pets' individual needs, other medications they may be on, and/or the issue that initially caused your pet to be placed on this medication. Many dog owners may wish to see their dogs stop vomiting when on Cerenia, but it may be upsetting as well dealing with a dog who doesn't want to eat. Cerenia is also used to treat acute nausea and vomiting in dogs and can alleviate nausea associated with chemotherapy. Discover what type of coat the Havanese dog breed has and its main characteristics. However, long road trips, airplane travel, or other modes of transportation may cause your pet to get motion sickness, which then leads to vomiting. Entyce works like your dog's naturally-occurring "hunger hormone" to trigger the feeling of hunger, leading your dog to eat. This is about 8.7 percent. When dog owners report side effects of Cerenia in dogs, it may be therefore difficult to prove whether the dog is truly suffering from side effects from this drug or from complications deriving from the underlying cause of the vomiting itself. Cereniatablets should be stored at controlled room temperatures between 68-77F and brief exposure to temperatures 59-86F are acceptable. Try to keep your pets diet as all-natural as possible. Maropitant is the non-proprietary designation for a substituted quinuclidine. This content shouldnt take the place of advice by your vet. Administer Cerenia Tablets orally at a minimum dose of 2 mg/kg (0.9 mg/lb) body weight once daily for up to 5 consecutive days. Yes, there are several alternatives to Cerenia for treating nausea and vomiting in dogs. Its also important to follow the prescribed dose and avoid giving your dog too much or too little of the medication. The dosage and duration of treatment may need to be adjusted based on the puppys size and medical history. Comment * document.getElementById("comment").setAttribute( "id", "ad0525e3af1c9e907f49c8d743428c54" );document.getElementById("ae31964646").setAttribute( "id", "comment" ); Save my name, email, and website in this browser for the next time I comment. "~Clinician's Brief. The safety of Cerenia has also been assessed when used concurrently with other common therapies, such as vaccinations, anthelmintics, dewormers, diagnostics, antibiotics, and anti-inflammatories. Cerenia is primarily used to control nausea and vomiting in cats, including motion sickness. While the drug is well tolerated in dogs, a higher dosage may cause side effects. Based upon in vitro enzyme kinetics, involvement of a high capacity enzyme (CYP3A12) may contribute to this return to dose linearity. The following adverse reactions were reported during US studies for the prevention of vomiting due to motion sickness in dogs treated with Cerenia Tablets at a minimum of 8 mg/kg orally one time. The body is often an amazing, yet underestimated entity when it comes to curing itself naturally. Uncommon side effects include: Allergic reaction Diarrhea Poor appetite Lethargy Uncoordinated walking Tremors Injectable Cerenia may cause pain and swelling at the injection site. However, its essential to follow your vets instructions carefully and avoid giving your dog too much of the medication. Cerenia is a safe and effective drug for the treatment of vomiting in dogs. Additionally, some dogs in the study tested positive for canine parvovirus, however, clinical parvoviral disease was not definitively diagnosed. Cerenia generic name maropitant, is often prescribed to dogs with a history of acute vomiting. The most common side effects seen in dogs and cats administered CERENIA are pain/vocalization (injectable), depression/lethargy, anorexia, anaphylaxis, ataxia, convulsions, hypersalivation, and vomiting. The only common side effect of Cerenia includes pain on injection, which resolves within seconds. Call your vet or pharmacist if you have additional questions or concerns about the use of Cerenia. Available for Android and iOS devices. The probability that a dog in this study, prone to motion sickness would NOT vomit during a journey if treated with Cerenia Tablets was 93%, while the probability was 48% if treated with placebo. Therefore, if you give a pet cimetidine and one of these other drugs (theophylline, aminophylline, lidocaine, and diazepam, to name a few), it is more likely that a pet will develop side effects similar to those seen with overdoses of the drug in question. In the most severe case, dogs may act as though they are experiencing a burning sensation. This is because the drug can affect the central nervous system and cause your dog to feel tired or sleepy. Youll want to make sure there is adequate assistance nearby. Another appetite stimulant is Cerenia (Maropitant Citrate), a common anti vomiting medication for both dogs and cats.