Erratum in: Clin Rheumatol. Effects of cerebral ischemia-reperfusion on pharmacokinetic fate of paeoniflorin after intravenous administration of Paeoniae Radix extract in rats. View abstract. Phytother.Res. Chin, Y. W., Jung, H. A., Liu, Y., Su, B. N., Castoro, J. Sheehan MP, Atherton DJ. View abstract. They also have a range of other intriguing activities. Suzuki H, Ohta Y, Takino T, and et al. Yamaguchi, H., Kidachi, Y., Kamiie, K., Noshita, T., Umetsu, H., and Ryoyama, K. Glycyrrhetinic acid induces anoikis-like death and cytoskeletal disruption in the central nervous system tumorigenic cells. A 2020 review found that licorice root extract can help reduce the growth of . Neurology 2010;75(21):1939-1941. View abstract. Peony and Licorice is a safe and gentle yet powerful formula that is famous for its ability to build blood and balance menstrual cycles. 1. Goto, F., Asama, Y., and Ogawa, K. Sho-saiko-to-ka-kikyo-sekko as an alternative treatment for chronic tonsillitis to avoid surgery. J Hepatol 1994;21:601-9. View abstract. Paeonia lactiflora : Peony is another popular anti-androgenic herb. View abstract. We currently have no information for PEONY overview. Minerva Med 2008;99(1):91-94. Case Rep Emerg Med. Am J Chin Med 1996;24:165-8. Licorice is an herb that grows in parts of Europe and Asia. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Mumoli, N. and Cei, M. Licorice-induced hypokalemia. Grebeniuk, V. N., Mannanov, A. M., Korsun, V. F., and Vinogradova, A. I. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Xie HJ, Yasar U, Sandberg M, Rane A. Paeoniae Radix, a traditional Chinese medicine, and CYP2C9 activity. View abstract. The immediate effect of Shakuyaku-kanzo-to, traditional Japanese herbal medicine, for muscular cramps during maintenance hemodialysis. Licorice is an herb that grows in parts of Europe and Asia. Postgrad Med J 1980;56(657):526-529. Although some people believe that peony tea is the tea with the lowest caffeine levels, actually peony tea has a high caffeine level, as much as 5%. Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial. This might decrease the effects of midazolam. Am.J Chin Med 2004;32(4):569-578. Crean, A. M., Abdel-Rahman, S. E., and Greenwood, J. P. A sweet tooth as the root cause of cardiac arrest. A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. Ir J Med Sci 2016;185(4):945-7. Ngan LT, Moon JK, Shibamoto T, Ahn YJ. Birth outcome in relation to licorice consumption during pregnancy. It is often used together with peony, which can significantly enhance . Digestion 2004;69:45-52. J Clin Psychopharmacol 2016;36(6):572-9. Lee, S. M., Li, M. L., Tse, Y. C., Leung, S. C., Lee, M. M., Tsui, S. K., Fung, K. P., Lee, C. Y., and Waye, M. M. Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. View abstract. J Ethnopharmacol. The yellow-brown thick-branched roots are used as medicine. 1988;8(11):660-2, 645. Med Princ Pract 2010;19(6):485-489. View abstract. Caradonna, P., Gentiloni, N., Servidei, S., Perrone, G. A., Greco, A. V., and Russo, M. A. Zhang YD, Lorenzo B, Reidenberg MM. View abstract. Contact Dermatitis 1989; 20:152-3.. View abstract. Fuhrman, B., Volkova, N., Kaplan, M., Presser, D., Attias, J., Hayek, T., and Aviram, M. Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure. 17. Fujisawa, Y., Sakamoto, M., Matsushita, M., Fujita, T., and Nishioka, K. Glycyrrhizin inhibits the lytic pathway of complement--possible mechanism of its anti-inflammatory effect on liver cells in viral hepatitis. Effect of licorice on reduction of body fat mass in healthy subjects. [13] A study in Japan compared the use of a . Armanini D, Lewicka S, Pratesi C, et al. Wang Y, Ma R. [Effect of an extract of Paeonia lactiflora on the blood coagulative and fibrinolytic enzymes]. "It contains liquiritin, an active compound that helps to disperse and remove existing melanin in the skin," explains Chwalek. Wen Y, Tang Y, Li M, Lai Y. View abstract. This information may not fit your specific health circumstances. Wong, A. L. and Chan, T. Y. Interaction between warfarin and the herbal product quilinggao. 83rd Annual Meeting of the Endocrine Society, June 20-23 2001;abstract P1-573. View abstract. WebMD does not provide medical advice, diagnosis or treatment. View abstract. View abstract. View abstract. However, when Angelica Sinensis was tested in combination with products containing other substances, its activity was reduced. View abstract. Lin, J. C. Mechanism of action of glycyrrhizic acid in inhibition of Epstein-Barr virus replication in vitro. B., and Zhang, Z. J. Effects of Paeonia lactiflora root extracts on the secretions of monocyte chemotactic protein-1 and -3 in human nasal fibroblasts. Ai, M., Yamaguchi, T., Odaka, T., Mitsuhashi, K., Shishido, T., Yan, J., Seza, A., and Saisho, H. Objective assessment of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy. J Endocrinol Invest 1990;13(10):847-848. Asia Pac.J Clin Nutr 2008;17(1):17-22. Ned.Tijdschr Geneeskd. Int Immunopharmacol 2012;14(1):27-31. Phytother Res 1988;2(3):140-145. Allergic contact dermatitis to Glycyrrhiza inflata root extract in an anti-acne cosmetic product. PCOS; Fertility; 25 - 45; Menopause; 45 - 60; Pregnancy Int Urol Nephrol. Am J Med Sci 2003;325:153-6. Licorice might decrease how quickly the body breaks down methotrexate. View abstract. View abstract. J Clin Psychopharmacol 2008;28(3):264-370. 2019;35:329-41. All rights reserved. Kormann R, Languille E, Amiot HM, Hertig A. View abstract. Isaia, G. C., Pellissetto, C., Ravazzoli, M., and Tamone, C. Acute adrenal crisis and hypercalcemia in a patient assuming high liquorice doses. Inflammopharmacology 2022;30(2):477-486. B. Prieto JM, Recio MC, Giner RM, et al. View abstract. Biofactors 2009;35(1):98-104. Yoon JY, Cha JM, Hong SS, et al. The invention belongs to the field of biopesticides, and mainly discloses a nuisanceless biological compound pesticide and a preparation method thereof. Peony (Paeonia spp). View abstract. View abstract. 1998;111(7):585-587. Armanini D, Bonanni G, Palermo M. Reduction of serum testosterone in men by licorice. Evid Based Complement Alternat Med 2016;2016:8292486. View abstract. Helpful. Gao, X., Wang, W., Wei, S., and Li, W. [Review of pharmacological effects of Glycyrrhiza radix and its bioactive compounds]. Paeoniae Radix-containing herbal medicine for patients with restless legs syndrome: A systematic review and meta-analysis. Medically reviewed by Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT By Kirsten Nunez on October 16, 2020. View abstract. View abstract. No side effects or changes in liver function tests occurred during the study. WebMD does not provide medical advice, diagnosis or treatment. Int Hepatol Comm 1997;233-238. Berlango Jimenez A., Jimenez Murillo L., Montero Perez F. J., Munoz Avila J. View abstract. Cancer 1997;79(8):1494-1500. Purnak, T., Ozaslan, E., Beyazit, Y., and Haznedaroglu, I. C. Upper gastrointestinal bleeding in a patient with defective hemostasis successfully treated with ankaferd blood stopper. Report of 2 cases and review of the literature. View abstract. View abstract. Hypokalemic paralysis due to licorice consumption is extremely rare, with only 40 cases in the English literature describing paralysis secondary to exposure to licorice in candies, medications, chewing tobacco, and herbal preparations. Nephol Dial Transplant 1999;14:218-20. View abstract. Armanini D, De Palo CB, Mattarello MJ, et al. Additional reporting by Meghan De Maria. Cumming, A. M., Boddy, K., Brown, J. J., Fraser, R., Lever, A. F., Padfield, P. L., and Robertson, J. I. 2020;383(13):1263-1275. Bardhan, K. D., Cumberland, D. C., Dixon, R. A., and Holdsworth, C. D. Clinical trial of deglycyrrhizinised liquorice in gastric ulcer. View abstract. Peony root might decrease the amount of phenytoin in the body. 2020. Preterm birth and licorice consumption during pregnancy. Brouwers, A. J. and van der, Meulen J. Dehours E, Vall B, Roug-Bugat ME, Florent B, Bounes V, Franchitto N. Suspected hypokalaemia following liquorice ingestion on board ship. Bernardi, M., D'Intino, P. E., Trevisani, F., Cantelli-Forti, G., Raggi, M. A., Turchetto, E., and Gasbarrini, G. Effects of prolonged ingestion of graded doses of licorice by healthy volunteers. Life Sci 2005;78:413-20 . Phytother Res 2009;23(2):246-250. Celik, M. M., Karakus, A., Zeren, C., Demir, M., Bayarogullari, H., Duru, M., and Al, M. Licorice induced hypokalemia, edema, and thrombocytopenia. View abstract. 2001;21(7):501-503. J Altern Complement Med 2009;15(4):439-443. View abstract. Licorice consumption and serum testosterone in healthy man. A man in Massachusetts died after eating too much black licorice, which contains a compound known to be toxic in large doses, according to a new report. Zhong.Xi.Yi.Jie.He.Za Zhi. Steroids 2005;70(8):538-542. Br J Clin Pharmacol 2008;66:572-4. Kumada T, et al. Effects of glycyrrhizin on the pharmacokinetics of nobiletin in rats and its potential mechanism. Fitoterapia 2006;77(7-8):613-614. Effects of mouthwash interventions on xerostomia and unstimulated whole saliva flow rate among hemodialysis patients: a randomized controlled study. Information from this source is evidence-based and objective, and without commercial influence. Lozenge-induced hypermineralcorticoid state--a unique case of licorice lozenges resulting in hypertension and hypokalemia. 1991;11(4):199-202, 195. View abstract. J Clin Anesth 2019;54:25-32. Nasal irrigation with Glycyrrhiza glabra extract for treatment of allergic rhinitis - A study of in vitro, in vivo and clinical trial. Some sources claim that it's contraindicated during pregnancy . View abstract. Peters, M. C., Tallman, J. View abstract. Visavadiya, N. P. and Narasimhacharya, A. V. Hypocholesterolaemic and antioxidant effects of Glycyrrhiza glabra (Linn) in rats. Qraa Advanced Lacto Dark Underarm Whitening Cream Product Claims Qraa underarm whitening cream claims to lighten dark underarms by reducing melanin from the skin in the area. B., and Zhang, Z. J. Eur J Drug Metab Pharmacokinet. 2020;2020:3727682. View abstract. Licorice root contains glycyrrhizin, which can cause side effects when eaten in large amounts. This versatile anti-inflammatory plant can benefit digestive issues, hormone health, and skin health as well as helping ease problems with menstruation and menopause. View abstract. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Cardiovasc.Drugs Ther 1998;12(6):599-600. Licorice might change how quickly the liver breaks down these medications. View abstract. Side effects, toxicity, and interactions. Kroes, B. H., Beukelman, C. J., van den Berg, A. J., Wolbink, G. J., van Dijk, H., and Labadie, R. P. Inhibition of human complement by beta-glycyrrhetinic acid. View abstract. Yasue H, Itoh T, Mizuno Y, Harada E. Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice. Liquorice and hypertension. Part 182 -- Substances Generally Recognized As Safe. View abstract. 2018 Jan;37(1):35-42. doi: 10.1007/s10067-017-3770-y. Concomitant Use of High-dose Methotrexate and Glycyrrhizin Affects Pharmacokinetics of Methotrexate, Resulting in Hepatic Toxicity. View abstract. Postgrad Med 2017;129(3):329-31. 2013 Jun;22(2):173-8. A Rutgers expert discusses how eating black licorice can affect your health. Some possible side effects with oral use include rash, itching, nasal symptoms, or stomach discomfort, but these are uncommon. G Ital Dermatol Venereol 2010;145(6):789-792. View abstract. Eriksson JW, Carlberg B, Hillom V. Life-threatening ventricular tachycardia due to liquorice-induced hypokalemia. View abstract. Phytother Res 2008;22:563-5. View abstract. View abstract. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Mouthwash Containing Glycyrrhiza uralensis Extract for Preventing Dental Caries. Paeoniflorin: an antihyperlipidemic agent from Paeonia lactiflora. View abstract. Plant Description. Licorice has been used as a medicinal plant from 2.500 years. View abstract. J Clin Endocrinol Metab 2003;88:2384-92. Guo TL, Zhou XW. View abstract. Liu C, Wang J, Yang J. Patients received either bromocriptine 5 mg daily for 4 weeks followed by 4 weeks of 22.5 grams daily of the peony-licorice decoction (equivalent to 25 mg of glycyrrhetinic acid), or the same drugs in the reverse order. Part 2: Effect of glycyrrhizic acid on the course of illness]. Altern Med Rev 1999;4(3):178-188. typica. View abstract. View abstract. [Clinical observation on auxiliary treatment of hormone dependence dermatitis by shufeng liangxue decoction]. Review of over-the-counter treatments for aphthous ulceration and results from use of a dissolving oral patch containing glycyrrhiza complex herbal extract. Pak J Med Sci 2022;38(1):271-275. Anesth Analg 2009;109(1):77-81. The roots are commonly used in Traditional Chinese Medicine (TCM) for many purposes. View abstract. Nat Prod Res 2007;21(14):1234-1241. View abstract. Fugh-Berman, A. Herb-drug interactions. View abstract. View abstract. Licorice is Sita (cold) in nature, Guru (heavy) to digest, and Madhura (sweet) in . Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. One of its most known effects is the induction of hypertension, and it can induce what appears to be pseudohyperaldosteronism, due to glycyrrhetinic acid, the main active component of the root. Phytother Res 2008;22(6):709-724. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. View abstract. Another type of licorice, called DGL or deglycyrrhizinated licorice, does not seem to have the same side effects and is sometimes used to treat peptic ulcers, canker sores, and reflux (GERD). View abstract. 2010;16(4):216-218. Proanthocyanidins, flavonoids, tannins, polysaccharides, and paeoniflorin are all considered to contribute to the medicinal activity of various forms of peony. Drug Metab Dispos 2002;30:709-15.. View abstract. Contact Dermatitis Due to Paeonia (Peony). Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions. Lozano, P., Flores, D., Martinez, S., Artigues, I., Rimbau, E. M., and Gomez, F. Upper limb ischemia induced by chronic licorice ingestion. Lancet 2003;361:2045-6.. View abstract. Melzer J, Rosch W, Reichling J, et al. Tooth decay. Endocrinol Jpn 1991;38(2):167-174. Biol Pharm Bull 2007;30(11):2191-2195. Monitor your blood pressure closely. Martin, M. D., Sherman, J., van der Ven, V., and Burgess, J. Aoki, F., Nakagawa, K., Kitano, M., Ikematsu, H., Nakamura, K., Yokota, S., Tominaga, Y., Arai, N., and Mae, T. Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans. Licorice reduces body fat mass in obese men and women. Nutrition 2002;18(3):268-273. Eur J Clin Pharmacol 2010;66(8):805-810. View abstract. Am J Chin Med 1992;20(3-4):313-317. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Blood Press. Yu IC, Tsai YF, Fang JT, Yeh MM, Fang JY, Liu CY. Harada M, Suzuki M, Ozaki Y. Morris DJ, Davis E, Latif SA. Chang GH, Lin YS, Hsu KH, et al. Gallacher SD, Tsokolas G, Dimitropoulos I. Liquorice-induced apparent mineralocorticoid excess presenting in the emergency department. Phytother.Res 2004;18(3):241-243. The author has contributed to research in topic(s): Rheum officinale. Zhongguo Zhong Xi Yi Jie He Za Zhi. Chin Med J (Engl.) Pathogenetic considerations and presentation of a clinical case]. Effects of low-dose liquorice alone or in combination with hydrochlorothiazide on the plasma potassium in healthy volunteers. Overview. View abstract. View abstract. (Doses up to 60 grams daily for up to 4 months have been used without reported adverse effects.) Lee, S. J., Lee, I. S., and Mar, W. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose in murine macrophage cells. People who regularly take large amounts of licorice, more than 20 g/day, may raise blood levels of the hormone aldosterone, which can cause serious side effects, including headache, high blood pressure, and heart problems. View abstract. Chemical studies of Chinese licorice-roots. View abstract. The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9. Not too many side effects of peony tea that we need to worry about. Lee, S. J., Lee, H. M., Ji, S. T., Lee, S. R., Mar, W., and Gho, Y. S. 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor. [Treatment of refractory polycystic ovary syndrome by bushen huoxue method combined with ultrasound-guided follicle aspiration]. Prevention of maternal-fetal blood group incompatibility with traditional Chinese herbal medicine. View abstract. Balakrishnan, V., Pillai, M. V., Raveendran, P. M., and Nair, C. S. Deglycyrrhizinated liquorice in the treatment of chronic duodenal ulcer. Treatment of duodenal ulcer with glycyrrhizinic-acid-reduced liquorice. View abstract. Tamir S, Eizenberg M, Somjen D, et al. View abstract. Messier, C., Epifano, F., Genovese, S., and Grenier, D. Licorice and its potential beneficial effects in common oro-dental diseases. Deglycyrrhizinated liquorice in duodenal ulcer. J Contemp.Dent Pract. [Clinical study on treatment of mid-advanced crescentic nephritis by qingre huoxue recipe]. Jin, C. Y., Wang, D. L., and Fang, Z. D. [Effect of integrative Chinese and Western medicine in treating chronic urticaria and its impact on interleukin-10 and interleukin-8 in peripheral blood]. View abstract. View abstract. Licorice that has the active ingredient of glycyrrhiza can have serious side effects. View abstract. View abstract. Ultrastruct Pathol 1992;16(5):529-535. 2005 - 2023 WebMD LLC. View abstract. van Marle J, Aarsen PN, Lind A, van Weeren-Kramer J. Deglycyrrhizinised liquorice (DGL) and the renewal of rat stomach epithelium. View abstract. Antiviral Res 1987;7(3):127-137. A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. Some medications are changed and broken down by the liver. Farese RV Jr, Biglieri EG, Shackleton CH, et al. Brush, J., Mendenhall, E., Guggenheim, A., Chan, T., Connelly, E., Soumyanath, A., Buresh, R., Barrett, R., and Zwickey, H. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. Peony and its major constituent, paeoniflorin, improve radial maze performance impaired by scopolamine in rats. Licorice might increase how quickly midazolam is broken down by the body. Rosenblat, M. and Aviram, M. Paraoxonases role in the prevention of cardiovascular diseases. View abstract. View abstract. Intern Med 2017;56(2):175-9. View abstract. Grapefruit juice and its flavonoids inhibit 11 beta-hydroxysteroid dehydrogenase. View abstract. J Intern Med 1999;245:307-10. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.